We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

The COVID-19 crisis has served not just to instil fear in the populace but to highlight the importance of fear as a motivating dynamic in politics. The gradual emergence of political-philosophical approaches calling for concern for ‘positive’ emotions may have made sense under non-pandemic conditions. Now, however, describing fear in the face of a deadly pandemic as ‘irrational’ or born of ‘ignorance’ seems ‘irrational’ and ‘ignorant’. In this article, we draw upon the work of John Gray and behavioural science to (...) present a defence of fear. We show how the pandemic has highlighted deficits in the work of four thinkers highly critical of fear: Martha Nussbaum, Zygmunt Bauman, Hannah Arendt and Sara Ahmed. We argue that, if such approaches are to be of value in anything other than optimal conditions, then they have to acknowledge the fundamental role of fear in helping human beings to pursue fundamental interests. (shrink)

Social distancing has become the most prominent measure many countries have implemented to combat the spread of COVID-19. The aim of the current study was to explore the potential role of empathy and self-construal styles, as individual personality traits, on self-reported social distancing. Participants completed the Interpersonal Reactivity Index, the Singelis Self-Construal Scale, and were asked to rate their level of social distancing and how much they endorsed social distancing on a five-point Likert-scale. Across a large and diverse sample, results (...) showed that trait-levels of empathic concern and perspective taking positively correlates with social distancing. However, we did not find evidence to suggest that trait-levels of personal distress correlates with social distancing. We interpret these findings as suggesting that empathy, both its altruistic and cognitive dimensions, plays an important role in motivating people to socially distance and should be emphasized during times of crisis. Furthermore, we suggest that emphasizing a person’s self-distress during times of crisis may not be an effective approach in promotion social distancing policies. We also found that both independence and interdependence self-construal styles positively correlates with social distancing. While we expected the latter result, we did not expect the former. This suggests that more work is needed to fully understand how self-construal styles, along with their cultural level analogs, influences social distancing. Overall, these results provide us with novel multi-national data about the role of individual differences on social distancing tendencies specifically, and human behavior during a global health crisis more generally. (shrink)

RESUMEN Una vez que el foco de la reflexión pasa de las teorías ideales a la aplicación de la justicia social, centrada en las instituciones de las sociedades democráticas, se requiere prestar especial atención a los estilos de vida. Estos tienen una alta incidencia en cómo la justicia es realizada y afectan tanto a la desigualdad económica como a la disponibilidad de los recursos naturales. En nuestras sociedades es posible establecer restricciones a los estilos de vida, especialmente en aquellos casos (...) en que, por el efecto de algunas dinámicas sociales, aquellos se desacoplan de las concepciones del bien. Se defiende que, en tales casos, la base normativa que permite exigir el respeto a los estilos de vida se disuelve y por ello es posible justificar su restricción. ABSTRACT Now that the focus of reflection has shifted from ideal theories to the application of social justice, centered on the institutions of democratic societies, it is necessary to pay special attention to lifestyles, since they not only influence the realization of justice, but also have an effect on economic inequality and the availability of natural resources. In our societies, it is possible to place restrictions on lifestyles, especially in those cases in which, influenced by certain social dynamics, they disengage from conceptions of the good. The article argues that, in those cases, the normative base grounding the demand that lifestyles be respected is dissolved, thus justifying their restriction. (shrink)

This handbook unites leading scholars from around the world in exploring anarchism as a political ideology, from an examination of its core principles, an analysis of its history, and an assessment of its contribution to the struggles that face humanity today. Grounded in a conceptual and historical approach, each entry charts what is distinctive about the anarchist response to particular intellectual, political, cultural and social phenomena, and considers how these values have changed over time. At its heart is a sustained (...) process of conceptual definition and an extended examination of the core claims of this frequently misunderstood political tradition. It is the definitive scholarly reference work on anarchism as a political ideology, and should be a crucial text for scholars, students, and activists alike. (shrink)

Until quite recently, mind-body dualism has been regarded with deep suspicion by both philosophers and scientists. This has largely been due to the widespread identification of dualism in general with one particular version of it: the interactionist substance dualism of Réné Descartes. This traditional form of dualism has, ever since its first formulation in the seventeenth century, attracted numerous philosophical objections and is now almost universally rejected in scientific circles as empirically inadequate. During the last few years, however, renewed attention (...) has begun to be paid to the dualistic point of view, as a result of increasing discontent with the prevailing materialism and reductionism of contemporary scientific and philosophical thought. Awareness has grown that dualism need not be restricted to its traditional form and that other varieties of dualism are not subject to the difficulties commonly raised against Descartes' own version of it. -/- Interest in these alternative versions of dualism is growing fast today, because it seems that they are capable of capturing deep-seated philosophical intuitions, while also being fully consistent with the methodological assumptions and empirical findings of modern scientific work on the human mind and brain. The object of this book is to provide philosophers, scientists, their students, and the wider general public with an up-to-date overview of current developments in dualistic conceptions of the mind in contemporary philosophy and science. (shrink)

In a fictional conversation designed to appeal to both working teachers and social philosophers, three educators take up the question of whether critical thinking itself can, or should, be taught independently of an explicit consideration of issues related to social justice. One, a thoughtful but somewhat traditional Enlightenment rationalist, sees critical thinking as a neutral set of skills and dispositions, essentially unrelated to the conclusions of morality, problems of social organization, or the content of any particular academic discipline. A second (...) interlocutor, steeped in “critical” pedagogy of Paulo Freire, insists that the problem is the pose of neutrality itself. On this view, all honest and effective approaches to teaching must confront the hegemony of unjust relationships, institutions, and conceptual schemes. The third character attempts to resolve the tension between these two opposed camps. (shrink)

In a fictional conversation designed to appeal to both working teachers and social philosophers, three educators take up the question of whether critical thinking itself can, or should, be taught independently of an explicit consideration of issues related to social justice. One, a thoughtful but somewhat traditional Enlightenment rationalist, sees critical thinking as a neutral set of skills and dispositions, essentially unrelated to the conclusions of morality, problems of social organization, or the content of any particular academic discipline. A second (...) interlocutor, steeped in “critical” pedagogy of Paulo Freire, insists that the problem is the pose of neutrality itself. On this view, all honest and effective approaches to teaching must confront the hegemony of unjust relationships, institutions, and conceptual schemes. The third character attempts to resolve the tension between these two opposed camps. (shrink)

This dialogue discusses a proposal for the legalization of torture under specific circumstances and contrasts it with arguments for a total ban on torture. We consider three types of objection: first, that the difficulty of having adequate knowledge renders the stock “ticking bomb” scenario such a low-probability hypothetical as to present no realistic threat to a policy banning all torture; second, that empirically the information gleaned from torture is so unlikely to be reliable that it could not justify the moral (...) risk; and third, that sanctioning torture, even if only under the most extreme circumstances, would generate a ‘culture of torture,’ hence undermining fragile advances in international human rights rooted in unwavering commitment to human dignity. Compelling as these arguments appear, not all the conversants are wholly convinced by them; to this extent the dialogue ends aporetically. (shrink)

This dialogue discusses a proposal for the legalization of torture under specific circumstances and contrasts it with arguments for a total ban on torture. We consider three types of objection: first, that the difficulty of having adequate knowledge renders the stock “ticking bomb” scenario such a low-probability hypothetical as to present no realistic threat to a policy banning all torture; second, that empirically the information gleaned from torture is so unlikely to be reliable that it could not justify the moral (...) risk; and third, that sanctioning torture, even if only under the most extreme circumstances, would generate a ‘culture of torture,’ hence undermining fragile advances in international human rights rooted in unwavering commitment to human dignity. Compelling as these arguments appear, not all the conversants are wholly convinced by them; to this extent the dialogue ends aporetically. (shrink)

Testimony is an indispensable way of gaining knowledge and also a voluntary act for which the teller can be held responsible. This dissertation analyzes these two aspects of testimony, the epistemological and the normative. Indeed, it argues that these two aspects cannot be separated: A satisfactory account of testimony's epistemology must allow for testimony's normative status, while an account of testimony's normative status can be derived from testimony's epistemology. ;Epistemologically, the general reliability of testimony should be treated differently from the (...) reliability of particular pieces of testimony. We are justified in believing that testimony is generally reliable, without needing evidence to that effect. This avoids the problems that would arise from attempting to gather evidence for testimony's general reliability. Particular pieces of testimony, however, can only provide a justification for belief by providing evidence for what is told. This view about particular pieces of testimony faces the problem of how the teller can present her testimony as evidence while accepting responsibility for it, and how the hearer can take testimony as evidence while holding the hearer responsible for it. ;To solve this problem, I give an account, based on inference to the best explanation, of the specific way testimony provides evidence for what is told. To see testimony as evidence for what is told, we must explain it in terms of the reasons people have for choosing to say one thing rather than another. On this account, the evidence that testimony provides depends on the teller's choice to assume responsibility for her testimony, rather than precluding that assumption of responsibility. ;On the other hand, the epistemology of testimony imposes certain norms on the act of telling someone something. The teller is responsible for the truth of her testimony, in that she stakes her future credibility on its truth. Loss of credibility would count as a sanction for violating the responsibility to tell the truth, because a teller ordinarily intends her testimony to be believed. This responsibility to tell the truth is derived from the epistemology of testimony. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

We examined participants' reading and recall of informed consent documents presented via paper or computer. Within each presentation medium, we presented the document as a continuous or paginated document to simulate common computer and paper presentation formats. Participants took slightly longer to read paginated and computer informed consent documents and recalled slightly more information from the paginated documents. We concluded that obtaining informed consent online is not substantially different than obtaining it via paper presentation. We also provide suggestions for improving (...) informed consent-in both face-to-face and online experiments. (shrink)

This article draws upon clinical experience of GPs working in a deprived area of the North East of England to examine the potential contribution of Universal Basic Income to health by mitigating ‘patient-side barriers’ among three cohorts experiencing distinct forms of ‘precariousness’: 1) long-term unemployed welfare recipients with low levels of education (lumpenprecariat); 2) workers on short-term/zero-hours contracts with low levels of education (‘lower’ precariat); 3) workers on short-term/zero-hours contracts with relatively high levels of education (‘upper’ precariat). We argue that (...) any benefits must be accompanied by robust institutions capable of promoting health. (shrink)

Knowledge of the law and its impact on health outcomes is increasingly important in public health practice. The CDC's Public Health Law Academy helps satisfy this need by providing online trainings, facilitator toolkits, and legal epidemiology tools to aid practitioners in learning about the law's role in promoting public health.

_ Source: _Page Count 20 Research by Graham and Haidt suggests that beliefs, rituals, and other social aspects of religion establish moral communities. As such, they suggest religion is most strongly associated with the group-focused “binding” moral foundations of ingroup/loyalty, authority/respect, and purity/sanctity. Two studies tested this hypothesis, investigating the role of political orientation in these relationships. These studies supported our hypothesis that general religiosity is positively associated with each of the group-focused moral foundations, even when controlling for the role (...) of political orientation. Further, we find religious and political orientations interact such that low-religious political liberals are least likely to endorse group-focused moral intuitions. Results are discussed in a moral foundations framework and consider the role of religiosity’s association with political orientation and group-focused moral foundations. (shrink)

We live in a world that is increasingly shaped by and bathed in science, with most scientific progress occurring in the past century, and much of it in the past few decades. Yet, several authors have puz- zled over the observation that modern societies are also characterized by a high degree of belief in a variety of pseudoscientific claims that have been thoroughly debunked or otherwise discarded by scientists (Anonymous, 2001; Ede, 2000).

The decision of the German regional court in Cologne on 26 June 2012 to prohibit the circumcision of minors is important insofar as it recognises the qualitative similarities between the practice and other prohibited invasive rites, such as female genital cutting. However, recognition of similarity poses serious questions with regard to liberal public policy, specifically with regard to the exceptionalist treatment demanded by certain circumcising groups. In this paper, I seek to advance egalitarian means of dealing with invasive rites which (...) take seriously cultural diversity, minimise harm and place responsibility for the burdens and consequences of beliefs upon those who promote practices. (shrink)

Firearm violence is a major public health problem in the United States. In 2000, firearms were used in 10,801 homicides – two-thirds of all homicides in the U.S. – and 533,470 non-fatal criminal victimizations including rapes, robberies, and assaults. The social costs of gun violence in the United States are also staggering, and have been estimated to be on the order of $100 billion per year.Illegal gun carrying, usually concealed, in public places is an important risk factor for firearm-related crime. (...) In the 1980s and 1990s, police departments across the country began to develop and implement strategies to address illegal weapons carrying. Often these strategies have involved aggressive efforts to identify and physically search individuals suspected of illegally carrying a firearm. (shrink)

Firearm violence is a major public health problem in the United States. In 2000, firearms were used in 10,801 homicides – two-thirds of all homicides in the U.S. – and 533,470 non-fatal criminal victimizations including rapes, robberies, and assaults. The social costs of gun violence in the United States are also staggering, and have been estimated to be on the order of $100 billion per year.Illegal gun carrying, usually concealed, in public places is an important risk factor for firearm-related crime. (...) In the 1980s and 1990s, police departments across the country began to develop and implement strategies to address illegal weapons carrying. Often these strategies have involved aggressive efforts to identify and physically search individuals suspected of illegally carrying a firearm. (shrink)

Common sense is not enough -- The "new archaeology" -- Archaeology as a science -- Middle-range theory, ethnoarchaeology, and material culture studies -- Culture and process -- Thoughts and ideologies -- Postprocessual and interpretative archaeologies -- Archaeology, gender, and identity -- Archaeology and cultural evolution -- Archaeology and Darwinian evolution -- Archaeology and history -- Archaeology, politics and culture -- Conclusion : the future of theory.

One interpretation of the conditional If P then Q is as saying that the probability of Q given P is high. This is an interpretation suggested by Adams (1966) and pursued more recently by Edgington (1995). Of course, this probabilistic conditional is nonmonotonic, that is, if the probability of Q given P is high, and R implies P, it need not follow that the probability of Q given R is high. If we were confident of concluding Q from the fact (...) that we knew P, and we have stronger information R, we can no longer be confident of Q. We show nonetheless that usually we would still be justified in concluding Q from R. In other words, probabilistic conditionals are mostly monotonic. (shrink)

The aim of this article is to review and reconsider what scholars, including historians, archaeologists, and those in other disciplines, are trying to get at when they attempt a “social interpretation” of English late medieval domestic buildings. I focus on the definition and interpretation of “meaning,” and I examine critically a series of concepts routinely deployed in social interpretations in the past, including my own work, such as type, zeitgeist, and intention. I argue that some of these concepts and interpretive (...) moves are problematic and rather than aiding in our understanding, raise further questions in their turn about how buildings were lived in and understood by their medieval inhabitants. I argue for a shift in language and jargon away from “planning” and “meaning” to that of “lived experience”. I explore such a possible shift with reference to different understandings of and debates over the late medieval castle of Bodiam in southeastern England. Such a shift from meaning to lived experience raises fresh challenges for the development and empirical evaluation of interdisciplinary research on medieval buildings, but it also raises fresh possibilities and insights. (shrink)

With everything from answers to frequent new-teacher questions and warnings of common new teacher pitfalls to specific strategies and veteran tricks useful for clawing back precious hours of the day, Matthew Johnson gives clear tips and clear reasons for them in a straightforward, jargonless voice and a mixture of practicality and philosophy.

From which evaluative base should we develop public policies designed to promote wellbeing among different cultural groups in different circumstances? This article attempts to advance an objective, universal theory of cultural evaluation grounded in a eudaemonistic account of human wellbeing. The approach evaluates cultures on the success with which they enable societies to promote the wellbeing of individuals through provision of needs and capabilities within their given, determinate circumstances. This provides the basis for a normative functionalism capable of identifying and (...) explaining cultural deficits. (shrink)

This article provides an account of the ethical issues that arise when digital technologies and online spaces are structured by Big Data algorithms. We show that although the uses of Big Data may be new, traditional theological and ethical categories are still applicable, including “the sins of the fathers” from hamartiology and the scholastic concept of haecceity. Using these resources, we map the overall ecosystem in which digital technologies are developed and used, identifying the relationships between the individuals and organizations (...) involved. We show how these relationships are often characterized by various kinds of harm. We then argue for a reorientation of the tech ecosystem toward co‐liberation—and ultimately, joy. (shrink)

At a time of COVID-19 pandemic, universal basic income (UBI) has been presented as a potential public health ‘upstream intervention’. Research indicates a possible impact on health by reducing poverty, fostering health-promoting behaviour and ameliorating biopsychosocial pathways to health. This novel case for UBI as a public health measure is starting to receive attention from a range of political positions and organisations. However, discussion of the ethical underpinnings of UBI as a public health policy is sparse. This is depriving policymakers (...) of clear perspectives about the reasons for, restrictions to and potential for the policy’s design and implementation. In this article, we note prospective pathways to impact on health in order to assess fit with Rawlsian, capabilities and perfectionist approaches to public health policy. We suggest that Raz’ pluralist perfectionist approach may fit most comfortably with the prospective pathways to impact, which has implications for allocation of resources. (shrink)